The heart of Prellis Bio’s strategy is the combination of novel, cutting edge methods in machine learning, biology at scale and next gen antibody discovery that address long-standing industry-wide problems in the drug development pipeline. Prellis Biologics uses proprietary technology to 3D print human lymph node organoids enabling the rapid & diverse discovery of human antibody therapeutic candidates for a range of applications.To drive this forward, we are assembling an incredible team of discovery biologists, computational scientists, and protein scientists who want to make a difference to this important problem.

Our Next-Generation Sequencing (NGS) group isseeking a motivated and energetic Associate NGS Scientist to join our team. at the junction of andbiologics discovery. The qualified candidate will be hands-on in molecular biology, responsible forexecuting cutting-edgeNGS workflows, and eager to work in a dynamic, cross-functional environment focused on rapid antibody candidate identification.

Responsibilities

• Execute and establish high-throughput single B cell VH-VL recovery and NGS workflows (e.g., 10xGenomics, CITE-Seq)from diverse discovery sources, including organoid-derived B cells and immunized animals.
• Perform RNA/DNA extraction, cDNA synthesis, PCR amplification, and NGS library preparation.
• Conduct routine QC of sequencing libraries (Bioanalyzer/TapeStation, Qubit, qPCR) and coordinate sequencing operations with internal and external partners.
• Support antibody sequence/repertoire analysis and report generation.
• Collaborate cross-functionally with biology and expression teams to ensure successful progression of pipeline projects.
• Maintain accurate and complete experimental records in electronic lab notebooks (ELN) and contribute to SOP development and optimization.
• Participate in troubleshooting, continuous improvement, and scalability efforts for high-throughput sequencing pipelines.

Qualifications

• BSc or M.S. in Molecular Biology, Genetics, Biotechnology, or related field with 3+ years of relevant professional experience.
• Demonstrated hands-on experience in single B cell sequencing techniques (e.g., 10x Genomics, CITE-Seq, FACS B cells).
• Working knowledge/experience in NGSlibrary prep, QC, and sequencer operation.
• Comfortable working with LIMS/ELN systems, and basic data handling in Excel.
• Strong organizational skills, attention to detail, and ability to work in a fast-paced, team-oriented environment.
• Excellent written and interpersonal communication skills
• Demonstrated experience in working collaboratively across various scientific disciplines
• Good initiative and ability to work independently with minimal supervision

Preferred Experience

• Direct experience in biotech or academic antibody discovery programs.
• Working knowledge in B cell immunology or antibody biology.
• Familiarity with automated liquid handlers or high-throughput molecular biology workflows.
• Interest in complex data analysis and visualization.

About Prellis Biologics

At Prellis, we integrate human biology with machine learning. We aim to revolutionize drug discovery by harnessing the power of the human immune system to develop next-generation antibody therapeutics with unparalleled speed, precision, and safety. We are committed to empowering our pharmaceutical partners with access to the most promising, fully human antibody candidates rapidly identified from the human immune repertoire.

Prellis Biologics is a pre-IPO biotech located in Berkeley, CA, with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline targets high unmet patient needs across therapeutic areas, including metabolic, inflammation, and oncology diseases. Our investors include Celesta, Khosla Ventures, SOSV, and Avidity Partners.

What You Can Expect From Us

As we work to develop treatments that take care of others, we also care for your professional and personal growth and well-being. From our collaborative culture to opportunities for learning and impact, you’ll be supported every step of the way.

Actual salary will vary based on several factors including but not limited to, relevant skills, experience, and qualifications.

Benefits In addition to the base salary, Prellis offers compelling benefits based on eligibility, comprising of health and welfare plans for staff and eligible dependents, financial plans with opportunities to save towards retirement or other goals, work/life balance, and career development opportunities that may include:

• A competitive employee benefits package, including group medical, dental and vision coverage, life and disability insurance, flexible spending accounts an a 401(k) plan
• Stock-based long term incentives
• Holiday package including a 1+ week winter shutdown
• Flexible work models, including remote and hybrid working arrangements, where possible

Application deadline Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.