Scientist / Senior Scientist – Antibody Analytical Characterization

Prellis Biologics is advancing next-generation antibody therapeutics by integrating machine learning, scalable biology, and proprietary 3D-printed human lymph node organoids. We are expanding our platform into complex antibody modalities to develop innovative biologic medicines, with programs spanning obesity, inflammation and immunology (I&I), and oncology.

Position Summary:

We are seeking a highly motivated Scientist or Senior Scientist with a strong background in therapeutic antibody characterization to join our therapeutics team. The successful candidate will contribute to the analytical assessment of monoclonal antibodies, bispecifics, and Fc-fusion proteins, supporting drug development through detailed biophysical and biochemical characterization.

Key Responsibilities:

• Perform comprehensive analytical characterization of therapeutic mAbs, bispecifics, and Fc-fusion proteins/antigens.
• Conduct biophysical and stability assessments including Tm, Tagg (Uncle), Size, AC-SINS, HIC, cIEF, aSEC, and BVP assays.
• Support formulation, developability, and comparability studies through analytical data generation and interpretation.
• Prepare clear and concise reports summarizing experimental results.
• Collaborate with cross-functional teams including process development, CMC, and Antibody Generation groups.
• Ensure adherence to laboratory safety, quality, and documentation standards.

Qualifications:

• MS or PhD in Biochemistry, Chemistry, Molecular Biology, or a related field.
• 2–3 years of industry experience with characterization of therapeutic antibodies, bispecifics, or Fc-fusion proteins.
• Strong hands-on experience with Tm, Tagg (Uncle), Size, AC-SINS, HIC, cIEF, aSEC, and BVP assays.
• Demonstrated ability to work independently and collaboratively in a team environment.
• Excellent problem-solving, organizational, and communication skills.

Preferred Skills:

• Experience in antibody developability, stability profiling, or comparability studies.
• Optional/Preferred: LC-MS-based antibody characterization (intact, subunit, peptide mapping) for detailed structural analysis.
• Knowledge of regulatory expectations for therapeutic biologics characterization.

About Prellis Biologics

At Prellis we integrate human biology with machine learning. We aim to revolutionized drug discovery by harnessing the power of human immune system with tightly, integrated machine learning to develop next-generation antibody therapeutics with unparalleled speed, precision and safety. We are committed to empowering our pharmaceutical partners with access to the most promising fully human body candidate rapidly identified from the human immune repertoire, enabling them to bring life-changing treatments to patients faster than ever before.

Prellis Biologics is a pre-IPO company located in Berkeley CA with a team-oriented, inclusive, and family-friendly culture. Our growing pipeline target high unmet patient needs across therapeutics including metabolic, inflammation, and autoimmune disease. Prellis has raised funding from top investors, including Celesta, Khosla Ventures, SOSV, & Avidity Partners

Application deadline

Prellis does not have an application deadline for this position; we will continue accepting applications until we receive a sufficient number or select a candidate for the position.

Prellis Bio is an equal opportunity employer. All applicants will be considered for employment without attention to race, color, religion, sex, sexual orientation, gender identity, national origin, veteran or disability status.

We believe diversity, equity, and inclusion need to be at the foundation of our culture. We work hard to bring together diverse teams–grounded in a wide range of expertise and life experiences–and work even harder to ensure those teams thrive in inclusive, growth-oriented environments supported by equitable company and team practices. All candidates can expect equitable treatment, respect, and fairness throughout the interview process.