Faeth Therapeutics is a clinical-stage oncology company listed on Nasdaq that recently raised $200M in funding. With a strong scientific foundation and a founding team that includes the discoverer of our target pathway, we are advancing PIKTOR, a multi-node PI3K/AKT/mTOR inhibitor program, toward multiple near-term milestones. We are a small, focused team where every person has direct impact — united by a shared commitment to care deeply, create boldly, and never stop learning.

The Vice President, Clinical Development will provide strategic and medical leadership across middle and late stage development for Faeth's oncology portfolio. This executive will serve as the senior medical leader for assigned programs, driving clinical strategy, providing medical oversight, and partnering cross-functionally to advance programs from late-stage development through regulatory approval.

This is a highly visible leadership role within a small, fast-paced biotechnology company where the successful candidate will influence company strategy, work directly with executive leadership, and help shape the future of the clinical development organization. The ideal candidate combines deep oncology expertise with hands-on execution, thrives in an entrepreneurial environment, and enjoys building alongside a collaborative team.

Reports to: Chief Medical Officer

Location: Remote (U.S.)

Responsibilities:

Clinical Development Strategy & Medical Leadership

• Lead the overall medical strategy for assigned oncology programs, ensuring scientific rigor, patient safety, and successful execution.
• Develop and present cross-functional team recommendations to the leadership team.
• Serve as the senior medical representative on cross-functional program teams, partnering closely with Clinical Operations, Regulatory Affairs, Biometrics, Translational Medicine, Pharmacovigilance, and Clinical Pharmacology.
• Contribute to overall portfolio strategy and clinical development planning.
• Represent the company with investigators, key opinion leaders, advisory boards, partners, and regulatory agencies.

Medical Monitoring & Patient Safety

• Support medical monitoring across the studies providing consistency and oversight.
• Provide ongoing medical oversight to ensure patient safety, protocol compliance, and high-quality clinical execution.
• Review eligibility assessments, protocol deviations, safety events, and emerging efficacy data.
• Partner with Pharmacovigilance to oversee SAE review, signal detection, benefit-risk assessments, and safety governance.

Clinical Data Review & Scientific Oversight

• Lead ongoing review and interpretation of clinical data to ensure scientific integrity and data quality.
• Identify emerging safety, efficacy, and operational trends to support informed development decisions.
• Partner with Clinical Operations, Data Management, and Biostatistics to ensure robust data quality and timely database locks.
• Guide interpretation of study results and support development of clinical study reports.

Regulatory & Scientific Leadership

• Provide medical leadership for regulatory interactions, including briefing documents, health authority meetings, INDs, NDAs/BLAs, and other regulatory submissions.
• Lead the medical review of protocols, informed consent documents, investigator brochures, and clinical study reports.
• Drive scientific communications including abstracts, manuscripts, congress presentations, and external publications.
• Support due diligence activities, business development opportunities, and strategic collaborations as appropriate.

Cross-Functional Leadership

• Provide medical leadership across a highly collaborative, matrixed organization.
• Mentor and influence cross-functional teams while fostering a culture of scientific excellence, accountability, and innovation.
• Contribute to company-wide initiatives beyond assigned programs as a key member of the clinical leadership team.

Requirements:

• M.D. degree with board certification and clinical experience as an attending physician.
• 5-10 years of experience in the biotechnology and/or pharmaceutical industry, with progressive medical leadership responsibilities.
• Experience within small biotechnology companies, with demonstrated success operating in lean, entrepreneurial environments.
• Significant experience in oncology drug development.
• Experience serving as Medical Monitor for interventional oncology clinical trials.
• Demonstrated experience leading cross-functional clinical development teams.
• Experience interpreting clinical data and guiding development decisions.
• Strong understanding of regulatory requirements and experience supporting interactions with global health authorities.
• Outstanding communication, executive presence, and stakeholder management skills.
• Highly collaborative with a hands-on, solution-oriented approach.

Preferred Experience:

• Clinical expertise in breast and/or endometrial oncology.
• Prior experience as an attending physician in oncology.

Compensation Range: $320,000 - $425,000 (actual compensation may vary based on experience, qualifications and location)

Working at Faeth

Benefits:

• Competitive salary and equity in a well-funded, clinical-stage biotech
• 100% remote work and flexible schedule
• Health, dental, and vision for you and your dependents
• Flexible time off
• Generous parental leave
• Traditional and Roth 401k
• Mission oriented, remote first culture

We are an equal opportunity employer, and we value diversity at our company. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.

All offers of employment are contingent upon satisfactory completion of a background check and verification of eligibility to work in the United States.